NEW! Low Dose Immunotherapy

Chronic allergies?
Food reactions that you haven’t been able to conquer?

Low Dose Immunotherapy may be for you!

Low Dose Immunotherapy (LDI) is a form of immune desensitization that works by restoring the tolerance for toxins or other foreign substances that induce an immune response in the body (antigens). This can be done for literally thousands of antigens at once to help your immune system better tolerate certain therapies.

LDI’s effect is accomplished by exposing your body to specific antigens (toxin or other foreign substance that induces an immune response in the body, especially the production of antibodies) at low doses. The tolerance is actively learned by your immune system and helps make your other treatments easier to tolerate, as well as potentially directly improving your condition.

The antigens are highly diluted. Substances that are diluted this way still have an impact on the immune system without the negative effects the undiluted antigen would have.


LDI is a fairly new treatment modality. Similar predecessors have been in use for decades. In the 1960s, Dr. Leonard McEwen pioneered the first type of immune desensitization called Enzyme Potentiated Desensitization (EPD). It is a form of immunotherapy that can treat different types of allergies. EPD evolved into Low Dose Allergen therapy (LDA) with the work of Dr. W.A Shrader Jr. Within the past few years, LDI has emerged as a further evolution to the earlier work of EPA/LDA. The most exciting shift from EPA/LDA to LDI is the ability to treat infectious agents.

LDI Sublingual Dosing

Sublingual dosing releases the dose quickly into your bloodstream. The syringe that comes to you for administration will not have a needle. There will be a very small amount of liquid in the end of the syringe.

Place the needleless syringe under your tongue and push down on the plunger. Once the antigen has been administered, you want to hold it under your tongue for 30 seconds, and then swallow.

The starting dose will be determined based on how sensitive you are, because it can be different for everyone, even using the same antigens for the same disease. Usually there are 7 weeks in between doses. If your symptoms flared, the next dose must be diluted, or may need to be given further apart.

How badly you flared, and how long you flared are critically important to determining your next dose. A flare is still good news – it means the therapy will work for you, just at a weaker dose. It can take several doses (six-plus months) to find the right dose. Report if you get better, how much better and for how long you felt good. If nothing happens you will need a stronger dose next time.

Adverse responses to LDI are uncommon and usually involve a mild to moderate exacerbation of existing sensitivity symptoms.


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